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The Rise of Superbugs: Answer Key to a Growing Global Threat
The headlines scream it: antibiotic-resistant bacteria, or "superbugs," are on the rise. This isn't science fiction; it's a terrifying reality with potentially devastating consequences for global health. This comprehensive guide serves as your "answer key" to understanding the rise of superbugs, exploring the causes, consequences, and potential solutions to this escalating crisis. We'll delve into the science behind antibiotic resistance, examine the factors driving its spread, and discuss strategies for combatting this alarming trend. Prepare to gain a deeper understanding of one of the most significant public health challenges of our time.
1. Understanding Antibiotic Resistance: The Science Behind Superbugs
Antibiotic resistance occurs when bacteria evolve mechanisms to survive exposure to antimicrobial drugs. This isn't a spontaneous mutation; it's a process driven by natural selection. When bacteria are exposed to antibiotics, those with even a slight resistance advantage are more likely to survive and reproduce, passing on their resistant genes. This leads to the proliferation of resistant strains, rendering previously effective treatments useless.
1.1 Mechanisms of Resistance:
Several mechanisms contribute to antibiotic resistance. Bacteria may develop enzymes that inactivate antibiotics, modify their target sites to prevent antibiotic binding, or actively pump antibiotics out of their cells. The precise mechanism varies depending on the bacterium and the antibiotic.
1.2 The Role of Horizontal Gene Transfer:
A crucial factor accelerating the spread of resistance is horizontal gene transfer. This process allows bacteria to exchange genetic material, including resistance genes, even between different species. This rapid dissemination of resistance genes significantly contributes to the emergence of multi-drug resistant organisms (MDROs).
2. Key Factors Driving the Rise of Superbugs
The alarming rise of superbugs isn't a singular event; it's a complex problem fueled by several interconnected factors:
2.1 Overuse and Misuse of Antibiotics:
The widespread overuse and misuse of antibiotics in both human and veterinary medicine is a primary driver. Over-prescription by healthcare professionals, patient non-compliance with treatment regimens, and the prophylactic use of antibiotics in agriculture all contribute to the selection pressure that favors resistant strains.
2.2 Inadequate Infection Control Practices:
Poor hygiene and inadequate infection control measures in healthcare settings facilitate the spread of resistant bacteria. This includes inadequate hand hygiene, contaminated equipment, and insufficient isolation procedures for infected patients.
2.3 Global Travel and Migration:
The increasing ease of global travel and migration accelerates the spread of resistant bacteria across geographical boundaries. Infected individuals can easily carry resistant strains to new locations, seeding outbreaks in previously unaffected areas.
3. The Consequences of Untreatable Infections
The rise of superbugs poses a significant threat to global health security. Untreatable infections can lead to:
3.1 Increased Morbidity and Mortality:
Resistant infections are associated with higher rates of morbidity (illness) and mortality (death). Patients with infections caused by superbugs are more likely to experience prolonged illness, require longer hospital stays, and face a greater risk of death.
3.2 Increased Healthcare Costs:
Treating resistant infections is significantly more expensive than treating susceptible infections. This is due to the need for more potent (and often more expensive) antibiotics, longer hospital stays, and the increased use of intensive care resources.
3.3 Threat to Modern Medicine:
The rise of superbugs threatens the efficacy of modern medicine. Many common surgical procedures and medical interventions become significantly riskier when the risk of untreatable infections increases.
4. Combating the Rise of Superbugs: Potential Solutions
Addressing the superbug crisis requires a multi-pronged approach:
4.1 Responsible Antibiotic Use:
Implementing stricter guidelines for antibiotic prescription and promoting responsible antibiotic stewardship programs are crucial. This includes educating healthcare professionals and the public about the appropriate use of antibiotics and discouraging unnecessary use.
4.2 Strengthening Infection Control:
Improving infection control practices in healthcare settings is essential to prevent the spread of resistant bacteria. This includes strengthening hygiene protocols, implementing robust sterilization procedures, and using appropriate isolation techniques.
4.3 Developing New Antimicrobials:
Investing in research and development of new antibiotics and other antimicrobial agents is vital. This includes exploring novel drug targets and developing alternative therapies to combat resistant bacteria.
4.4 Public Health Surveillance:
Robust public health surveillance systems are essential for tracking the emergence and spread of resistant bacteria. This allows for early detection of outbreaks and facilitates the implementation of timely control measures.
Conclusion
The rise of superbugs is a global health emergency that demands immediate attention. Addressing this challenge requires a concerted effort from healthcare professionals, policymakers, researchers, and the public. By implementing responsible antibiotic use, strengthening infection control measures, developing new antimicrobials, and enhancing public health surveillance, we can significantly mitigate the threat posed by these dangerous pathogens and safeguard the future of medicine.
FAQs
1. Can I get a superbug infection at home? While many superbug infections occur in healthcare settings, they can also be acquired in the community through contact with contaminated surfaces, food, or other individuals.
2. Are all antibiotics becoming ineffective? Not all antibiotics are losing effectiveness at the same rate. Some remain potent against many bacterial strains, while others are facing increasing resistance.
3. What can I do to prevent superbug infections? Practice good hygiene, such as frequent handwashing, avoid unnecessary antibiotic use, and follow your doctor’s instructions carefully if you are prescribed antibiotics.
4. Is there a "superbug vaccine"? While there isn't a single vaccine against all superbugs, research is underway to develop vaccines targeting specific resistant strains.
5. How long will it take to develop new antibiotics? Developing new antibiotics is a lengthy and complex process, often taking many years of research and development. The pipeline for new antibiotics is currently insufficient to meet the growing threat.
| rise of the superbugs answer key: Mechanisms of antibiotic resistance Jun Lin, Kunihiko Nishino, Marilyn C. Roberts, Marcelo Tolmasky, Rustam I. Aminov, Lixin Zhang, 2015-06-01 Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens. |
| rise of the superbugs answer key: Revenge of the Microbes Abigail A. Salyers, Dixie D. Whitt, 2005 A single source of answers to questions average people are asking. Appeals to a diverse readership, including biologists, doctors, teachers, students, lawyers, environmentalists, and average citizens. |
| rise of the superbugs answer key: Microbial Evolution and Co-Adaptation Institute of Medicine, Board on Global Health, Forum on Microbial Threats, 2009-05-10 Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions. |
| rise of the superbugs answer key: Superbug Maryn McKenna, 2010-03-23 LURKING in our homes, hospitals, schools, and farms is a terrifying pathogen that is evolving faster than the medical community can track it or drug developers can create antibiotics to quell it. That pathogen is MRSA—methicillin-resistant Staphyloccocus aureus—and Superbug is the first book to tell the story of its shocking spread and the alarming danger it poses to us all. Doctors long thought that MRSA was confined to hospitals and clinics, infecting almost exclusively those who were either already ill or old. But through remarkable reporting, including hundreds of interviews with the leading researchers and doctors tracking the deadly bacterium, acclaimed science journalist Maryn McKenna reveals the hidden history of MRSA’s relentless advance—how it has overwhelmed hospitals, assaulted families, and infiltrated agriculture and livestock, moving inexorably into the food chain. Taking readers into the medical centers where frustrated physicians must discard drug after drug as they struggle to keep patients alive, she discloses an explosion of cases that demonstrate how MRSA is growing more virulent, while evolving resistance to antibiotics with astonishing speed. It may infect us at any time, no matter how healthy we are; it is carried by a stunning number of our household pets; and it has been detected in food animals from cows to chickens to pigs. With the sensitivity of a novelist, McKenna portrays the emotional and financial devastation endured by MRSA’s victims, vividly describing the many stealthy ways in which the pathogen overtakes the body and the shock and grief of parents whose healthy children were felled by infection in just hours. Through dogged detective work, she discloses the unheard warnings that predicted the current crisis and lays bare the flaws that have allowed MRSA to rage out of control: misplaced government spending, inadequate public health surveillance, misguided agricultural practices, and vast overuse of the few precious drugs we have left. Empowering readers with the knowledge they need for self-defense, Superbug sounds an alarm: MRSA has evolved into a global emergency that touches almost every aspect of modern life. It is, as one deeply concerned researcher tells McKenna, the biggest thing since AIDS. |
| rise of the superbugs answer key: Exploring the Frontiers of Innovation to Tackle Microbial Threats National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Global Health, Forum on Microbial Threats, 2020-09-10 On December 4â€5, 2019, the National Academies of Sciences, Engineering, and Medicine held a 1.5-day public workshop titled Exploring the Frontiers of Innovation to Tackle Microbial Threats. The workshop participants examined major advances in scientific, technological, and social innovations against microbial threats. Such innovations include diagnostics, vaccines (both development and production), and antimicrobials, as well as nonpharmaceutical interventions and changes in surveillance. This publication summarizes the presentations and discussions from the workshop. |
| rise of the superbugs answer key: Probiotics in The Prevention and Management of Human Diseases Mitesh Kumar Dwivedi, N. Amaresan, A Sankaranaryanan, Helen Kemp, 2021-12-02 Probiotics in The Prevention and Management of Human Diseases: A Scientific Perspective addresses the use of probiotics and their mechanistic aspects in diverse human diseases. In particular, the mechanistic aspects of how these probiotics are involved in mitigating disease symptoms (novel approaches and immune-mechanisms induced by Probiotics), clinical trials of certain probiotics, and animal model studies will be presented through this book. In addition, the book covers the role of probiotics in prevention and management aspects of crucial human diseases, including multidrug resistant infections, hospital acquired infections, allergic conditions, autoimmune diseases, metabolic disorders, gastrointestinal diseases, neurological disorders, and cancers. Finally, the book addresses the use of probiotics as vaccine adjuvants and as a solution for nutritional health problems and describes the challenges of using probiotics in management of human disease conditions as well as their biosafety concerns. Intended for nutrition researchers, microbiologists, physiologists, and researchers in related disciplines as well as students studying these topics require a resource that addresses the specific role of probiotics in the prevention and management of human disease. - Contains information on the use of probiotics in significant human diseases, including antibiotic resistant microbial infections - Presents novel applications of probiotics, including their use in vaccine adjuvants and concept of pharmabiotics - Includes case studies and human clinical trials for probiotics in diverse disease conditions and explores the role of probiotics in mitigation of the symptoms of disease |
| rise of the superbugs answer key: Practical Implementation of an Antibiotic Stewardship Program Tamar F. Barlam, Melinda M. Neuhauser, Pranita D. Tamma, Kavita K. Trivedi, 2018-04-26 This practical reference guide from experts in the field details why and how to establish successful antibiotic stewardship programs. |
| rise of the superbugs answer key: Antibiotics and Antimicrobial Resistance Genes Muhammad Zaffar Hashmi, 2020-04-07 This volume summarizes and updates information about antibiotics and antimicrobial resistance (AMR)/antibiotic resistant genes (ARG) production, including their entry routes in soil, air, water and sediment, their use in hospital and associated waste, global and temporal trends in use and spread of antibiotics, AMR and ARG. Antimicrobial/antibiotic resistance genes due to manure and agricultural waste applications, bioavailability, biomonitoring, and their Epidemiological, ecological and public health effects. The book addresses the antibiotic and AMR/ARG risk assessment and treatment technologies, for managing antibiotics and AMR/ARG impacted environments The book's expert contributions span 20 chapters, and offer a comprehensive framework for better understanding and analyzing the environmental and social impacts of antibiotics and AMR/ARGs. Readers will have access to recent and updated models regarding the interpretation of antibiotics and AMR/ARGs in environment and biomonitoring studies, and will learn about the management options require to appropriately mitigate environmental contaminants and pollution. The book will be of interest to students, teachers, researchers, policy makers and environmental organizations. |
| rise of the superbugs answer key: The Fourth Industrial Revolution Klaus Schwab, 2017-01-03 The founder and executive chairman of the World Economic Forum on how the impending technological revolution will change our lives We are on the brink of the Fourth Industrial Revolution. And this one will be unlike any other in human history. Characterized by new technologies fusing the physical, digital and biological worlds, the Fourth Industrial Revolution will impact all disciplines, economies and industries - and it will do so at an unprecedented rate. World Economic Forum data predicts that by 2025 we will see: commercial use of nanomaterials 200 times stronger than steel and a million times thinner than human hair; the first transplant of a 3D-printed liver; 10% of all cars on US roads being driverless; and much more besides. In The Fourth Industrial Revolution, Schwab outlines the key technologies driving this revolution, discusses the major impacts on governments, businesses, civil society and individuals, and offers bold ideas for what can be done to shape a better future for all. |
| rise of the superbugs answer key: The Globalization of Crime United Nations Office on Drugs and Crime, 2010 In The globalization of crime: a transnational organized crime threat assessment, UNODC analyses a range of key transnational crime threats, including human trafficking, migrant smuggling, the illicit heroin and cocaine trades, cybercrime, maritime piracy and trafficking in environmental resources, firearms and counterfeit goods. The report also examines a number of cases where transnational organized crime and instability amplify each other to create vicious circles in which countries or even subregions may become locked. Thus, the report offers a striking view of the global dimensions of organized crime today. |
| rise of the superbugs answer key: The impact of disasters and crises on agriculture and food security: 2021 Food and Agriculture Organization of the United Nations , 2021-03-17 On top of a decade of exacerbated disaster loss, exceptional global heat, retreating ice and rising sea levels, humanity and our food security face a range of new and unprecedented hazards, such as megafires, extreme weather events, desert locust swarms of magnitudes previously unseen, and the COVID-19 pandemic. Agriculture underpins the livelihoods of over 2.5 billion people – most of them in low-income developing countries – and remains a key driver of development. At no other point in history has agriculture been faced with such an array of familiar and unfamiliar risks, interacting in a hyperconnected world and a precipitously changing landscape. And agriculture continues to absorb a disproportionate share of the damage and loss wrought by disasters. Their growing frequency and intensity, along with the systemic nature of risk, are upending people’s lives, devastating livelihoods, and jeopardizing our entire food system. This report makes a powerful case for investing in resilience and disaster risk reduction – especially data gathering and analysis for evidence informed action – to ensure agriculture’s crucial role in achieving the future we want. |
| rise of the superbugs answer key: Infections and Inequalities Paul Farmer, 2001-02-23 Annotation A report from the front lines of the war against the most deadly epidemics of our times, by a physician-anthropolpgist who has for over 15 years sought to serve the poor of rural Haiti and other settings in the Americas. |
| rise of the superbugs answer key: The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus Shymaa Enany, Laura Crotty Alexander, 2017-03-08 Staphylococcus aureus S. aureus is a growing issue both within hospitals and community because of its virulence determinants and the continuing emergence of new strains resistant to antimicrobiotics. In this book, we present the state of the art of S. aureus virulence mechanisms and antibiotic-resistance profiles, providing an unprecedented and comprehensive collection of up-to-date research about the evolution, dissemination, and mechanisms of different staphylococcal antimicrobial resistance patterns alongside bacterial virulence determinants and their impact in the medical field. We include several review chapters to allow readers to better understand the mechanisms of methicillin resistance, glycopeptide resistance, and horizontal gene transfer and the effects of alterations in S. aureus membranes and cell walls on drug resistance. In addition, we include chapters dedicated to unveiling S. aureus pathogenicity with the most current research available on S. aureus exfoliative toxins, enterotoxins, surface proteins, biofilm, and defensive responses of S. aureus to antibiotic treatment. |
| rise of the superbugs answer key: Body by Darwin Jeremy Taylor, 2015-10-22 This exploration of cutting-edge evolutionary medicine and how our body’s performance is shaped by its past “covers fascinating territory” (Publishers Weekly). We think of medical science and doctors as focused on treating conditions—whether it’s a cough or an aching back. But the sicknesses and complaints that cause us to seek medical attention actually have deeper origins than the superficial germs and behaviors we regularly fault. In fact, as Jeremy Taylor shows in Body by Darwin, we can trace the roots of many medical conditions through our evolutionary history, revealing what has made us susceptible to certain illnesses and ailments over time and how we can use that knowledge to help treat or prevent problems in the future. In Body by Darwin, Taylor examines the evolutionary origins of some of our most common and serious health issues. To begin, he looks at the hygiene hypothesis, which argues that our obsession with anti-bacterial cleanliness, particularly at a young age, may be making us more vulnerable to autoimmune and allergic diseases. He also discusses diseases of the eye, the medical consequences of bipedalism as they relate to all those aches and pains in our backs and knees, the rise of Alzheimer’s disease, and how cancers become so malignant that they kill us despite the toxic chemotherapy we throw at them. Taylor explains why it helps to think about heart disease in relation to the demands of an ever-growing, dense, muscular pump that requires increasing amounts of nutrients, and he discusses how walking upright and giving birth to ever larger babies led to a problematic compromise in the design of the female spine and pelvis. Throughout, he not only explores the impact of evolution on human form and function, but integrates science with stories from actual patients and doctors, closely examining the implications for our health. “Seven vivid true stories dramatically describing patients and their doctors discovering evolutionary explanations for diseases. More than just the perfect book club book, it advances the field of evolutionary medicine.” —Randolph M. Nesse, coauthor of Why We Get Sick |
| rise of the superbugs answer key: Your Medical Mind Jerome Groopman, Pamela Hartzband, 2012-08-28 Drs. Groopman and Hartzband reveal a clear path for making the right medical choices. Such factors as authority figures, statistics, other patients' stories, technology, and natural healing are key factors that shape choices. |
| rise of the superbugs answer key: Antibiotic Drug Resistance José-Luis Capelo-Martínez, Gilberto Igrejas, 2019-09-24 This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies |
| rise of the superbugs answer key: Missing Microbes Martin Blaser, 2014-06-02 A clarion call to save humanity’s most essential fellow creatures – and our health Far beneath our skin exists an unfathomable, ancient universe – an internal ecosystem that is critical to our health. Dr Martin Blaser invites us into the wilds of the human ‘microbiome’, unfurling its inner workings and evolution. For thousands of years, bacteria and human cells have co-existed in a relationship that has ensured the health and equilibrium of our body. But now, much like the natural world outside of us, our internal environment is being irrevocably destroyed. The culprit: some of our most revered medical advances – antibiotics – which appear to be linked to the epidemics of asthma, eczema, obesity, certain forms of cancer, and other diseases plaguing modern society. In a book that stands as the Silent Spring of its day, Blaser sounds a provocative alarm that we ignore at our peril. |
| rise of the superbugs answer key: Antibiotic Resistance Institute of Medicine, Board on Global Health, Forum on Microbial Threats, 2011-01-10 Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs. |
| rise of the superbugs answer key: Antiviral Drug Resistance Douglas D. Richman, 1996-12-02 The study of antiviral drug resistance has provided important insights into the structure of virus enzymes, the functions of certain genes, mechanisms of action of antiviral drugs, the design of new antiviral compounds and the pathogenesis of viral diseases. The emergence of resistant strains must be explored at all stages of drug development: during the preclinical evaluation of candidate compounds; during the early clinical evaluation of new drugs; and as part of epidemiological surveillance for the prevalence of resistance during use of approved treatments. Accumulating understanding of antiviral drug resistance thus reflects progress in the chemotherapy of viral infection. Antiviral Drug Resistance provides state-of-the-art coverage of the basic and clinical aspects of this subject. It deals with the basic science, including the mechanisms of drug resistance and drug action, genetics of drug resistance, cross resistance, and X-ray crystallographic structural aspects of resistance, as well as the clinical aspects, including issues of assay of susceptibility of clinical isolates, descriptive aspects of emergence of reduced susceptibility, and clinical significance and impact of resistance. As such this unique volume will be essential to basic researchers in drug discovery and viral pathogenesis, as well as clinicians involved in antiviral chemotherapy. |
| rise of the superbugs answer key: Viruses Vs. Superbugs T. Häusler, Thomas Häusler, 2016-05-24 Each year thousands of people die from bacteria resistant to antibiotics. Alternative drugs are urgently needed. A surprising ray of hope from the past are viruses that kill bacteria, but not us. Award-winning science journalist Thomas Häusler investigates how these long-forgotten cures may help sick people today. |
| rise of the superbugs answer key: Nanostructures for Antimicrobial Therapy Anton Ficai, Alexandru Mihai Grumezescu, 2017-05-29 Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. - Shows how nanoantibiotics can be used to more effectively treat disease - Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs - Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area |
| rise of the superbugs answer key: Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine National Academies Of Sciences Engineeri, National Academies of Sciences Engineering and Medicine, Health And Medicine Division, Board On Population Health And Public He, Board on Population Health and Public Health Practice, Committee on the Long-Term Health and Economic Effects of Antimicrobial Resistance in the United States, 2022-07-20 The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed. |
| rise of the superbugs answer key: Biodiversity and Human Health Francesca Grifo, Joshua Rosenthal, 1997-02-01 The implications of biodiversity loss for the global environment have been widely discussed, but only recently has attention been paid to its direct and serious effects on human health. Biodiversity loss affects the spread of human diseases, causes a loss of medical models, diminishes the supplies of raw materials for drug discovery and biotechnology, and threatens food production and water quality. Biodiversity and Human Health brings together leading thinkers on the global environment and biomedicine to explore the human health consequences of the loss of biological diversity. Based on a two-day conference sponsored by the National Institutes of Health, the National Science Foundation, and the Smithsonian Institution, the book opens a dialogue among experts from the fields of public health, biology, epidemiology, botany, ecology, demography, and pharmacology on this vital but often neglected concern. Contributors discuss the uses and significance of biodiversity to the practice of medicine today, and develop strategies for conservation of these critical resources. Topics examined include: the causes and consequences of biodiversity loss emerging infectious diseases and the loss of biodiversity the significance and use of both prescription and herbal biodiversity-derived remedies indigenous and local peoples and their health care systems sustainable use of biodiversity for medicine an agenda for the future In addition to the editors, contributors include Anthony Artuso, Byron Bailey, Jensa Bell, Bhaswati Bhattacharya, Michael Boyd, Mary S. Campbell, Eric Chivian, Paul Cox, Gordon Cragg, Andrew Dobson, Kate Duffy-Mazan, Robert Engelman, Paul Epstein, Alexandra S. Fairfield, John Grupenhoff, Daniel Janzen, Catherine A. Laughin, Katy Moran, Robert McCaleb, Thomas Mays, David Newman, Charles Peters, Walter Reid, and John Vandermeer. The book provides a common framework for physicians and biomedical researchers who wish to learn more about environmental concerns, and for members of the environmental community who desire a greater understanding of biomedical issues. |
| rise of the superbugs answer key: Superbugs Matt McCarthy, 2019-06-04 Drug-resistant bacteria — known as superbugs — are one of the biggest medical threats of our time. Here, a doctor, researcher, and ethics professor tells the exhilarating story of his race to beat them and save countless lives. When doctor Matt McCarthy first meets Jackson, a mechanic from Queens, it is in the ER, where he has come for treatment for an infected gunshot wound. Usually, antibiotics would be prescribed, but Jackson’s infection is one of a growing number of superbugs, bacteria that have built up resistance to known drugs. He only has one option, and if that doesn’t work he may lose his leg or even his life. On the same day, McCarthy and his mentor Tom Walsh begin work on a groundbreaking clinical trial for a new antibiotic they believe will eradicate certain kinds of superbugs and demonstrate to Big Pharma that investment in these drugs can save millions of lives and prove financially viable. But there are countless hoops to jump through before they can begin administering the drug to patients, and for people like Jackson time is in short supply. Superbugs is a compelling tale of medical ingenuity. From the muddy trenches of the First World War, where Alexander Fleming searched for a cure for soldiers with infected wounds, to breakthroughs in antibiotics and antifungals today that could revolutionise how infections are treated, McCarthy takes the reader on a roller-coaster ride through the history — and future — of medicine. Along the way, we meet patients like Remy, a teenage girl with a dangerous and rare infection; Donny, a retired firefighter with a compromised immune system; and Bill, the author’s own father-in-law, who contracts a deadly staph infection. And we learn about the ethics of medical research: why potentially life-saving treatments are often delayed for years to protect patients from exploitation. Can McCarthy get his trial approved and underway in time to save the lives of his countless patients infected with deadly bacteria, who have otherwise lost all hope? |
| rise of the superbugs answer key: The Perfect Predator Steffanie Strathdee, Thomas Patterson, 2019-02-26 An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. A memoir that reads like a thriller. -New York Times Book Review A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short. -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka the perfect predator, can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis. |
| rise of the superbugs answer key: Natural Products Lixin Zhang, Arnold L. Demain, 2007-11-17 A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious. |
| rise of the superbugs answer key: The Other End of the Microscope Elmer W. Koneman, 2002 Through the instrument of his fictional narrator, the extremophyle prokaryote Thermotoga maritima, the author tells the story of a convention of microbes convened for the purpose of rebutting human assigned taxonomic names. Disgruntled that humans often name them after some scientist of the place of their discovery, the microbes discuss their biology, function, adaptation to environments, defense against human attacks, and other activities in order to suggest that they should by named after their attributes. A final session invites entries for a renaming of homo sapiens that reflects the point of view of the microbes. Annotation copyrighted by Book News, Inc., Portland, OR. |
| rise of the superbugs answer key: Impacts of Antibiotic-resistant Bacteria , 1995 |
| rise of the superbugs answer key: Extending the Cure Ramanan Laxminarayan, Anup Malani, David Howard, David L. Smith, 2010-09-30 Our ability to treat common bacterial infections with antibiotics goes back only 65 years. However, the authors of this report make it clear that sustaining a supply of effective and affordable antibiotics cannot be without changes to the incentives facing patients, physicians, hospitals, insurers, and pharmaceutical manufacturers. In fact, increasing resistance to these drugs is already exacting a terrible price. Every day in the United States, approximately 172 men, women, and children die from infections caused by antibiotic-resistant bacteria in hospitals alone. Beyond those deaths, antibiotic resistance is costing billions of dollars through prolonged hospital stays and the need for doctors to resort to ever more costly drugs to use as substitute treatments. Extending the Cure presents the problem of antibiotic resistance as a conflict between individual decision makers and their short-term interest and the interest of society as a whole, in both present and future: The effort that doctors make to please each patient by prescribing a drug when it might not be properly indicated, poor monitoring of discharged patients to ensure that they do not transmit drug-resistant pathogens to other persons, excesses in the marketing of new antibiotics, and the broad overuse of antibiotics all contribute to the development and spread of antibiotic-resistant bacteria. The book explores a range of policy options that would encourage patients, health care providers, and managed care organizations to serve as more responsible stewards of existing antibiotics as well as proposals that would give pharmaceutical firms greater incentives to develop new antibiotics and avoid overselling. If the problem continues unaddressed, antibiotic resistance has the potential to derail the health care system and return us to a world where people of all ages routinely die from simple infections. As a basis for future research and a spur to a critically important dialogue, Extending the Cure is a fundamental first step in addressing this public health crisis. The Extending the Cure project is funded in part by the Robert Wood Johnson Foundation through its Pioneer Portfolio. |
| rise of the superbugs answer key: Small World Initiative: Research protocols Simon Hernandez, 2016 |
| rise of the superbugs answer key: The Dry Challenge Hilary Sheinbaum, 2020-12-29 “The definitive guide to giving up booze.”—People Foreword by Lo Bosworth For many people, drinking a glass of beer or wine after work is a part of everyday life. But did you know taking a break from drinking (even for just a month!) has extreme benefits and can be incredibly life-changing? From losing weight, to saving money, to sleeping better at night, the overall health and mental gains of going dry for a month are endless. Whether you’re eager to try Dry January or simply want to lessen your quarantine drinking habits in a positive and approachable way, as daunting as it may seem, you too can do it! Understandably, more and more people have been turning to alcohol as a coping mechanism to get through the pandemic, but maybe this is a good time to ask yourself: Are you waking up feeling out of sorts more often than you’d like to be? Offering friendly support and encouragement and filled with engaging activities to help you prepare –and complete – a full alcohol-free month, The Dry Challenge provides an easy step-by-step guide for completing your first Dry January, Sober October, or any other alcohol-free month. You’ll find plenty of booze-free activities from prompts to checklists to the best mocktail recipes around. From making a plan to sharing the news with friends and family (and what to do when someone tries to sabotage your boozeless journey) to getting back on track if you slip up and have a drink (or two), we got you covered. Trend journalist, on-air host, and lifestyle expert Hilary Sheinbaum has been participating in Dry January for the past four years. What started out as a bet with a friend to see who could go the longest without taking a sip of alcohol during January became a ritual she looked most forward to every year. As friends, family, and readers turned to her for advice on how to start their own dry month journeys, Hilary realized everyone’s motivations differed greatly. The decision to give up alcohol is deeply personal and making the choice to stop drinking for any length of time can be discouraging given how normalized alcohol culture is in our society. Have you noticed we use every celebratory event as an excuse to get our drink on? But you don’t have to do it alone! In The Dry Challenge, you’ll find a best friend support system ready to help you tackle the challenges of forgoing alcohol for a month and encourage you every step of the way to the finish line. In The Dry Challenge, you’ll: · Discover the health, mental, and financial benefits of living a month without booze · Learn how to combat social pressures from our current drinking culture · Find fun non-boozy activities everyone can participate in (including making delicious “zero-proof” drinks and throwing the best nonalcoholic shindigs) Gorgeously packaged and filled with bold colors and graphics, The Dry Challenge is the ultimate interactive guide to staying booze free for one month (yes, this includes champagne!). Written with humor, compassion, and insight, this book will help you achieve your goal of completing an alcohol-free month, one less drink at a time. |
| rise of the superbugs answer key: The End of an Antibiotic Era Rinke van den Brink, 2021-05-19 In this monograph, journalist Rinke van den Brink takes a closer look at the limitations and risks of today’s antibiotic use. Though all developed societies have grown accustomed to successfully treating bacterial infections with these wonder drugs, the author focuses on the increasing number of antibiotic-resistant infections. By examining recent mass outbreaks, readers will gain a better understanding of the global impact of antimicrobial resistance – one of the most serious public health threats today. Following this somewhat disquieting review of the status quo, interviews with a number of specialists provide an outlook on possible solutions. In a world that is more connected than ever, partnerships between different healthcare systems are becoming all the more important. Rinke van den Brink uses the example of a border-spanning collaboration between the Netherlands and Germany to demonstrate how effective lines of communication can be established. The book offers a wealth of useful background information for healthcare personnel. Not only does it share insights into the functional microbe-antibiotic relationship; it also discusses how clinics can effectively address outbreaks, helping readers to learn from past experiences and develop effective new strategies. |
| rise of the superbugs answer key: Penicillins and Cephalosporins Robert B. Morin, Marvin Gorman, 2014-05-10 Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists. |
| rise of the superbugs answer key: Escape the Coming Night David Jeremiah, 2001-11-10 No one can deny that the world is in trouble. Tragedy stalks our streets. Violence and bloodshed fill the news. How do we explain so much chaos? Is there any hope for peace in our time? Dr. David Jeremiah's dramatic narrative on the Book of Revelation answers these and many more challenging questions, by unraveling the imagery and explaining the significance of the events described in the last book of the Bible. Within its pages are the hope and encouragement we need to lift us from the gloom of present events to the promise of a brilliant future. |
| rise of the superbugs answer key: The Science and Applications of Synthetic and Systems Biology Institute of Medicine, Board on Global Health, Forum on Microbial Threats, 2011-12-30 Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary. |
| rise of the superbugs answer key: New edge of antibiotic development: antimicrobial peptides and corresponding resistance Octavio L. Franco, Nádia S. Parachin, 2014-09-26 Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects. |
| rise of the superbugs answer key: Ferri's Clinical Advisor 2021 Fred F. Ferri, 2020-06-10 Find fast answers to inform your daily diagnosis and treatment decisions! Ferri’s Clinical Advisor 2021 uses the popular 5 books in 1 format to deliver vast amounts of information in a clinically relevant, user-friendly manner. This bestselling reference has been significantly updated to provide you with easy access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, clinical algorithms, laboratory tests, and clinical practice guidelines—all carefully reviewed by experts in key clinical fields. Extensive algorithms, along with hundreds of new figures and tables, ensure that you stay current with today's medical practice. Contains significant updates throughout, covering all aspects of current diagnosis and treatment. Features 27 all-new topics including chronic rhinosinusitis, subclinical brain infarction, reflux-cough syndrome, radiation pneumonitis, catatonia, end-stage renal disease, and genitourinary syndrome of menopause, among others. Includes new appendices covering common herbs in integrated medicine and herbal activities against pain and chronic diseases; palliative care; and preoperative evaluation. Offers online access to Patient Teaching Guides in both English and Spanish. |
| rise of the superbugs answer key: A Global Perspective on Vaccines: Priorities, Challenges and Online Information Luciana Leite, Aldo Tagliabue, Rino Rappuoli, Odile Yvonne Leroy, 2020-03-04 |
| rise of the superbugs answer key: China Rx Rosemary Gibson, Janardan Prasad Singh, 2018-04-17 Millions of Americans are taking prescription drugs made in China and don't know it--and pharmaceutical companies are not eager to tell them. This is a disturbing, well-researched wake-up call for improving the current system of drug supply and manufacturing. Several decades ago, penicillin, vitamin C, and many other prescription and over-the-counter products were manufactured in the United States. But with the rise of globalization, antibiotics, antidepressants, birth control pills, blood pressure medicines, cancer drugs, among many others are made in China and sold in the United States. China's biggest impact on the US drug supply is making essential ingredients for thousands of medicines found in American homes and used in hospital intensive care units and operating rooms. The authors convincingly argue that there are at least two major problems with this scenario. First, it is inherently risky for the United States to become dependent on any one country as a source for vital medicines, especially given the uncertainties of geopolitics. For example, if an altercation in the South China Sea causes military personnel to be wounded, doctors may rely upon medicines with essential ingredients made by the adversary. Second, lapses in safety standards and quality control in Chinese manufacturing are a risk. Citing the concerns of FDA officials and insiders within the pharmaceutical industry, the authors document incidents of illness and death caused by contaminated medications that prompted reform. This probing book examines the implications of our reliance on China on the quality and availability of vital medicines. |
| rise of the superbugs answer key: Bacterial Virulence Anthony William Maresso, 2019-09-18 This textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting “out-of-the-box” thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health. This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms. |
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